drug-tolerant cancer cells show reduced tumor-initiating capacity depletion of cd44+ cells and evidence for epigenetic mechanismsdrug-tolerant癌细胞显示减少肿瘤起源容量损耗cd44 +细胞的表观遗传机制的证据.pdfVIP

Drug-Tolerant Cancer Cells Show Reduced Tumor- Initiating Capacity: Depletion of CD44+ Cells and Evidence for Epigenetic Mechanisms 1,2. 1,3. 1,4. 1 1 1 Hong Yan , Xin Chen , Qiuping Zhang , Jichao Qin , Hangwen Li , Can Liu , Tammy Calhoun- 1 1 5 6 6 6 Davis , Luis Della Coletta , Jim Klostergaard , Izabela Fokt , Stanislaw Skora , Waldemar Priebe , Yongyi Bi1, Dean G. Tang1,3,7* 1 Department of Molecular Carcinogenesis, the University of Texas M.D. Anderson Cancer Center, Smithville, Texas, United States of America, 2 Wuhan University School of Public Health, Wuhan, Hubei, China, 3 Program in Molecular Carcinogenesis, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America, 4 Department of Immunology, Wuhan University School of Basic Medical Science, Wuhan, Hubei, China, 5 Department of Molecular and Cellular Oncology, the University of Texas, M.D. Anderson Cancer Center, Houston, Texas, United States of America, 6 Department of Experimental Therapeutics, the University of Texas, M.D. Anderson Cancer Center, Houston, Texas, United States of America, 7 Centers for Cancer Epigenetics, Stem Cell and Developmental Biology, RNA Interference and Non-coding RNAs, and Molecular Carcinogenesis, the University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America Abstract Cancer stem cells (CSCs) possess high tumor-initiating capacity and have been reported to be resistant to therapeutics. Vice versa, therapy-resistant cancer cells seem to manifest CSC phenotypes and properties. It has been generally assumed that drug-resistant cancer cells may