ebola virus genome plasticity as a marker of its passaging history a comparison of in vitro passaging to non-human primate infection埃博拉病毒基因组可塑性的一个标志使历史比较体外使非人类灵长类动物感染.pdfVIP

Ebola Virus Genome Plasticity as a Marker of Its Passaging History: A Comparison of In Vitro Passaging to Non-Human Primate Infection 1 1,6 4 1 3 Jeffrey R. Kugelman , Michael S. Lee , Cynthia A. Rossi , Sarah E. McCarthy , Sheli R. Radoshitzky , 2 2 2 5 5 3 John M. Dye , Lisa E. Hensley , Anna Honko , Jens H. Kuhn , Peter B. Jahrling , Travis K. Warren , 1 3 1 Chris A. Whitehouse , Sina Bavari , Gustavo Palacios * 1 Genomics Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Maryland, United States of America, 2 Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Maryland, United States of America, 3 Toxicology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Maryland, United States of America, 4 Diagnostic Systems Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Maryland, United States of America, 5 Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Maryland, United States of America, 6 Simulation Sciences Branch, United States Army Research Laboratory, Aberdeen Proving Ground, Maryland, United States of America Abstract To identify polymorphic sites that could be used as biomarkers of Ebola virus passage history, we repeatedly amplified Ebola virus (Kikwit variant) in vitro