effect of homocysteine-lowering nutrients on blood lipids results from four randomised, placebo-controlled studies in healthy humanshomocysteine-lowering营养对血脂的影响结果从四个随机,安慰剂对照研究人类健康.pdfVIP

Open access, freely available online PLoS MEDICINE Effect of Homocysteine-Lowering Nutrients on Blood Lipids: Results from Four Randomised, Placebo-Controlled Studies in Healthy Humans 1* 2 1 1 1 Margreet R. Olthof , Trinette van Vliet , Petra Verhoef , Peter L. Zock , Martijn B. Katan 1 Wageningen Centre for Food Sciences and Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands, 2 TNO Quality of Life, Zeist, the Netherlands Competing Interests: The Wage- A B S T R A C T ningen Centre for Food Sciences (WCFS) is an alliance of six indus- trial partners (AVEBE, Cosun, Background CSM, DSM, Unilever, and NZO) and four research organizations (Wageningen University and Re- Betaine (trimethylglycine) lowers plasma homocysteine, a possible risk factor for search Centre, Maastricht Univer- cardiovascular disease. However, studies in renal patients and in obese individuals who are sity, NIZO Food Research, and TNO Quality of Life). Forty-seven on a weight-loss diet suggest that betaine supplementation raises blood cholesterol; data in percent of funding comes from the healthy individuals are lacking. Such an effect on cholesterol would counteract any favourable Dutch government, 29% from the industrial partners, and 24% from effect on homocysteine. We therefore investigated the effect of betaine, of its precursor choline the research institutes. The part- in the form of phosphatidylcholine, and of the classical homocysteine-lowering vitamin folic ners have no say over the mode or acid on blood lipid concentrations in healthy humans. content of publications res