efficient derivation of multipotent neural stemprogenitor cells from non-human primate embryonic stem cells高效的多功能神经stemprogenitor派生细胞非人类的灵长类动物的胚胎干细胞.pdfVIP

Efficient Derivation of Multipotent Neural Stem/ Progenitor Cells from Non-Human Primate Embryonic Stem Cells 1 2,3 . 2 5 5 6¤ Hiroko Shimada , Yohei Okada * , Keiji Ibata , Hayao Ebise , Shin-ichi Ota , Ikuo Tomioka , 2,4 2,6 2 2 2,6 Toshihiro Nomura , Takuji Maeda , Kazuhisa Kohda , Michisuke Yuzaki , Erika Sasaki , 1 2 . Masaya Nakamura , Hideyuki Okano * 1 Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan, 2 Department of Physiology, School of Medicine, Keio University, Tokyo, Japan, 3 Kanrinmaru Project, School of Medicine, Keio University, Tokyo, Japan, 4 Department of Pediatrics, School of Medicine, Keio University, Tokyo, Japan, 5 Genomic Science Laboratories, Dainippon Sumitomo Pharma Co. Ltd., Osaka, Japan, 6 Marmoset Research Department, Central Institute for Experimental Animals, Kanagawa, Japan Abstract The common marmoset (Callithrix jacchus) is a small New World primate that has been used as a non-human primate model for various biomedical studies. We previously demonstrated that transplantation of neural stem/progenitor cells (NS/PCs) derived from mouse and human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) promote functional locomotor recovery of mouse spinal cord injury models. However, for the clinical application of such a therapeutic approach, we need to evaluate the efficacy and safety of pluripotent stem cell-derived NS/