early-to-mid gestation fetal testosterone increases right hand 2d∶4d finger length ratio in polycystic ovary syndrome-like monkeysearly-to-mid妊娠胎儿睾丸激素增加右手2 d∶4 d手指长度比例多囊卵巢症状猴子.pdfVIP

Early-to-Mid Gestation Fetal Testosterone Increases Right Hand 2D:4D Finger Length Ratio in Polycystic Ovary Syndrome-Like Monkeys 1 1 1 1,4 1,2,3 Andrew D. Abbott *, Ricki J. Colman , Ross Tiefenthaler , Daniel A. Dumesic , David H. Abbott 1 Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin, United States of America, 2 Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin, United States of America, 3 Endocrinology-Reproductive Physiology Program, University of Wisconsin, Madison, Wisconsin, United States of America, 4 Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, United States of America Abstract A smaller length ratio for the second relative to the fourth finger (2D:4D) is repeatedly associated with fetal male-typical testosterone (T) and is implicated as a biomarker for a variety of traits and susceptibility to a number of diseases, but no experimental human studies have been performed. The present study utilizes the rhesus monkey, a close relative of humans, and employs discrete gestational exposure of female monkeys to fetal male-typical T levels for 15–35 days during early-to-mid (40–76 days; n = 7) or late (94–139 days; n = 7) gestation (term: 165 days) by daily subcutaneous injection of their dams with 10 mg T propionate. Such gestational exposures are known to enhance male-typical behavior. In this study, compared to control females (n = 19), only early-to-mid gestation T exposure virilizes female external genitalia while increasing 2D:4D ratio in the right hand (RH) by male-like elongation of