mortality associated with diabetes and cardiovascular disease in older women死亡率与糖尿病和心血管疾病在老年妇女.pdfVIP

Mortality Associated with Diabetes and Cardiovascular Disease in Older Women 1,2 3 1 4 5 David Nanchen *, Nicolas Rodondi , Jacques Cornuz , Teresa Hillier , Kristine E. Ensrud , Jane A. Cauley6, Douglas C. Bauer7 for the Study of Osteoporotic Fractures Research Group 1 Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland, 2 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, 3 Department of General Internal Medicine, University of Bern, Bern, Switzerland, 4 Center for Health Research, Kaiser Permanente Northwest/Hawaii, Portland, Oregon, United States of America, 5 Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, and Department of Medicine and Division of Epidemiology and Community Health, University of Minnesota, St. Paul, Minnesota, United States of America, 6 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 7 Division of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America Abstract Background: Current guidelines for the prevention of cardiovascular disease (CVD) recommend diabetes as a CVD risk equivalent. However, reports that have examined the risk of diabetes in comparison to pre-existing CVD are lacking among older women. We aimed to assess whether diabetes was associated with a similar risk of total and cause-specific mortality as a history of CVD in older women. Methodology/Principal Findings: We studied 9218 women aged 68 years or older enrolled in a prospective cohort study (Study of Osteoporotic Frac