role of mindin in diabetic nephropathymindin在糖尿病肾病中的作用.pdfVIP

Hindawi Publishing Corporation Experimental Diabetes Research Volume 2011, Article ID 486305, 6 pages doi:10.1155/2011/486305 Review Article Role of Mindin in Diabetic Nephropathy Maki Murakoshi, Tomohito Gohda, Mitsuo Tanimoto, Kazuhiko Funabiki, Satoshi Horikoshi, and Yasuhiko Tomino Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo 113-8421, Japan Correspondence should be addressed to Yasuhiko Tomino, yasu@juntendo.ac.jp Received 25 July 2011; Accepted 26 September 2011 Academic Editor: Yoshio Shimizu Copyright © 2011 Maki Murakoshi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A number of studies have shown that proinflammatory cytokines have important roles in determining the development of microvascular diabetic complications, including nephropathy. Inflammatory biomarkers should be useful for diagnosis or monitoring of diabetic nephropathy. Mindin (spondin 2) is a member of the mindin -/F-spondin family of secreted extracellular matrix (ECM) proteins. Recent studies showed that mindin is essential for initiation of innate immune response and represents a unique pattern-recognition molecule in the ECM. Previously, we demonstrated that the levels of urinary mindin in patients with type 2 diabetes were higher than those in healthy individuals. We propose that urinary mindin is a potent biomarker for the development of diabetic nephropathy. 1. Introduction basement membranes from nondiabetic rats [ 12]. Based on