serum metabolic profile in multiple sclerosis patients多发性硬化患者的血清代谢轮廓.pdfVIP

Hindawi Publishing Corporation Multiple Sclerosis International Volume 2011, Article ID 167156, 8 pages doi:10.1155/2011/167156 Research Article Serum Metabolic Profile in Multiple Sclerosis Patients Barbara Tavazzi,1 Anna Paola Batocchi,2 Angela Maria Amorini,1 Viviana Nociti,2 Serafina D’Urso,3 Salvatore Longo,3 Stefano Gullotta,3 Marika Picardi,1 and Giuseppe Lazzarino3 1 Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, 00168 Rome, Italy 2 Institute of Neurology, Catholic University of Rome, 00168 Rome, Italy 3 Department of Biology, Geology and Environmental Sciences, Division of Biochemistry and Molecular Biology, University of Catania, 95125 Catania, Italy Correspondence should be addressed to Giuseppe Lazzarino, lazzarig@unict.it Received 10 January 2011; Revised 30 March 2011; Accepted 2 May 2011 Academic Editor: Axel Petzold Copyright © 2011 Barbara Tavazzi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Multiple sclerosis (MS) is a progressive demyelinating process considered as an autoimmune disease, although the causes of this pathology have not been yet fully established. Similarly to other neurodegenerations, MS is characterized by a series of biochemical changes affecting to different extent neuronal functions; great attention has been given to oxidative/nitrosative stress and to alterations in mitochondrial functions. According to previous data, MS patients show significant changes in the circulating concentrations of different metabolites, although it is still unclear whether uric aci