spect imaging agents for detecting cerebral β-amyloid plaques检测脑spect显像剂β-amyloid斑块.pdfVIP

Hindawi Publishing Corporation International Journal of Molecular Imaging Volume 2011, Article ID 543267, 12 pages doi:10.1155/2011/543267 Review Article SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques Masahiro Ono and Hideo Saji Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan Correspondence should be addressed to Masahiro Ono, ono@pharm.kyoto-u.ac.jp and Hideo Saji, hsaji@pharm.kyoto-u.ac.jp Received 29 July 2010; Revised 6 November 2010; Accepted 24 January 2011 Academic Editor: Alexander Drzezga Copyright © 2011 M. Ono and H. Saji. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The development of radiotracers for use in vivo to image β -amyloid (Aβ ) plaques in cases of Alzheimer’s disease (AD) is an important, active area of research. The presence of Aβ aggregates in the brain is generally accepted as a hallmark of AD. Since the only definitive diagnosis of AD is by postmortem staining of affected brain tissue, the development of techniques which enable one to image Aβ plaques in vivo has been strongly desired. Furthermore, the quantitative evaluation of Aβ plaques in the brain could facilitate evaluation of the efficacy of antiamyloid therapies currently under development. This paper reviews the current situation in the development of agents for SPECT-based imaging of Aβ plaques in Alzheimer’s brains. 1. Introduction whereas Aβ is seen not at all or only sporadically in most of these other diseas