spore powder of ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy a pilot clinical trial灵芝孢子粉改善癌症相关疲劳乳腺癌患者接受内分泌治疗飞行员的临床试验.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 809614, 8 pages doi:10.1155/2012/809614 Research Article Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial Hong Zhao, Qingyuan Zhang, Ling Zhao, Xu Huang, Jincai Wang, and Xinmei Kang Department of Internal Medicine, The Third Affi liated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China Correspondence should be addressed to Qingyuan Zhang, honghuhu2009@ Received 24 May 2011; Accepted 1 September 2011 ´ ´ Academic Editor: Jose Luis Rıos Copyright © 2012 Hong Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The fatigue prevalence in breast cancer survivors is high during the endocrine treatment. However, there are few evidence-based interventions to manage this symptom. The aim of this study was to investigate the effectiveness of spore powder of Ganoderma lucidum for cancer-related fatigue in breast cancer patients undergoing endocrine therapy. Spore powder of Ganoderma lucidum is a kind of Basidiomycete which is a widely used traditional medicine in China. 48 breast cancer patients with cancer-related fatigue undergoing endocrine therapy were randomized into the experimental or control group. FACT-F, HADS, and EORTC QLQ-C30 questionnaires data were collected at baseline and 4 weeks after treatment. The concentrations of TNF-α, IL-6, and liver-kidney functions were measured before and after intervention. The experimental group showed sta