serum hepcidin levels and reticulocyte hemoglobin concentrations as indicators of the iron status of peritoneal dialysis patients血清hepcidin水平和网织红细胞血红蛋白浓度作为腹膜透析患者的铁状态的指标.pdfVIP

Hindawi Publishing Corporation International Journal of Nephrology Volume 2012, Article ID 239476, 7 pages doi:10.1155/2012/239476 Clinical Study Serum Hepcidin Levels and Reticulocyte Hemoglobin Concentrations as Indicators of the Iron Status of Peritoneal Dialysis Patients Aya Eguchi,1 Takahiro Mochizuki,2 Misao Tsukada,1 Koji Kataoka,2 Yukio Hamaguchi,3 Shinichiro Oguni,4 Kosaku Nitta,1 and Ken Tsuchiya1 1 Department of Medicine IV, Tokyo Women’s Medical University, Kawada-cho 8-1, Shinjuku, Tokyo 162-8666, Japan 2 Department of Nephrology, Kameda Medical Center, Higashi-machi 929, Kamogawa, Chiba 296-8602, Japan 3 Immunology Chemistry Product Engineering, ICH Business Unit, Sysmex Corporation, Wakihama, Kaigandori 1-5-1, Chuou-ku, Koube, Hyogo 651-0073, Japan 4 Clinical Development, Technology Development, Sysmex Corporation, Wakihama, Kaigandori 1-5-1, Chuou-ku, Koube, Hyogo 651-0073, Japan Correspondence should be addressed to Ken Tsuchiya, mm-ken@tkc.att.ne.jp Received 24 July 2012; Accepted 27 September 2012 Academic Editor: Kook-Hwan Oh Copyright © 2012 Aya Eguchi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hepcidin is the key mediator of renal anemia, and reliable measurement of serum hepcidin levels has been made possible by the ProteinChip system. We therefore investigated the iron status and serum hepcidin levels of peritoneal dialysis (PD) patients who had not received frequent doses of an erythrocytosis-stimulating agent (ESA) and had not received iron therapy. In addition to the usual iron parameters, the iron status of erythrocytes can be determined by measuring