stimulating effect of japanese herbal (kampo) medicine, hochuekkito on upper respiratory mucosal immune system刺激日本草药医学(邮政寿险局)的影响,hochuekkito上呼吸道粘膜免疫系统.pdfVIP

Advance Access Publication 24 June 2006 eCAM 2006;3(4)459–467 doi:10.1093/ecam/nel030 Original Article Stimulating Effect of Japanese Herbal (Kampo) Medicine, Hochuekkito on Upper Respiratory Mucosal Immune System 1,2 1,2 1,2 1 2 2 H. Kiyohara , T. Nagai , K. Munakata , K. Nonaka , T. Hanawa , S. J. Kim and H. Yamada1,2 1The Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University and 2Oriental Medicine Research Center, The Kitasato Institute, Tokyo, Japan Japanese herbal (Kampo) medicine, Hochuekkito (Bu-Zhong-Yi-Qi-Tang in Chinese, TJ-41) and Juzentaihoto (Shi-Quan-Da-Bu-Tang in Chinese, TJ-48) are well-known Kampo formulas used as tonic. Although these medicines have separately been applied to the patients clinically depending on their symptoms, the differences of the pharmacological activities for these medicines have not been fully understood. TJ-48 and TJ-41 were compared for their effects on antibody response in upper respiratory mucosal immune system in vivo. Oral administration of TJ-41 (100 mg kg1 per day) to early aged BALB/c mice, which were nasally sensitized with influenza hemagglutinin vaccine, significantly enhanced influenza virus-specific IgA and IgG antibody titers in nasal cavity and sera, respectively.