synthesis and antimicrobial studies of tridentate schiff base ligands with pyrazolone moiety and their metal complexes合成及抗菌药物的研究有三叉的席夫碱与吡唑啉酮基配体及其金属配合物.pdfVIP

Hindawi Publishing Corporation Organic Chemistry International Volume 2010, Article ID 648589, 7 pages doi:10.1155/2010/648589 Research Article Synthesis and Antimicrobial Studies of Tridentate Schiff Base Ligands with Pyrazolone Moiety and Their Metal Complexes Ramasamy Jayarajan, Gnanasambandam Vasuki, and Pillutla Sambasiva Rao Department of Chemistry, Pondicherry University, Puducherry 605 014, India Correspondence should be addressed to Gnanasambandam Vasuki, vasukig@ Received 8 September 2010; Revised 23 October 2010; Accepted 2 November 2010 Academic Editor: Feihe Huang Copyright © 2010 Ramasamy Jayarajan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Synthesis, characterization, and antimicrobial activity of tridentate Schiffbase ligands containing pyrazolone moiety (3a and 3b) and their transition metal complexes of VO(II), Cu(II), Fe(III), and Co(II) 4a–h have been investigated. The complexes show enhanced antibacterial activity against S. aureus, E. coli, and S. typhi and antifungal activity against C. albicans, Rhizopus sp., and A. niger compared to the ligands. 1. Introduction mainlyexists as the 3-methyl-1-phenyl-4-acetylpyrazolin-5-ol tautomer (2). Condensing (2) with 1,2-diaminobenzene, Developing metal-based drugs is emerging as an active area and 2-aminophenol resulted in ONN-and ONO-type tri- of research. Many organic ligands particularly tridentate dentate ligands (3a and 3b), respectively. Ligands 3a and Schiff base ligands s