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Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 954140, 5 pages doi:10.1093/ecam/nep069 Review Article The Budding Yeast “Saccharomyces cerevisiae ” as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties Bouchra Qaddouri,1 Abdelkarim Guaadaoui,1 Ahmed Bellirou,1 Abdellah Hamal,1 Ahmed Melhaoui,2 Grant W. Brown,3, 4 and Mohammed Bellaoui1, 5 1 Laboratoire de Genetique et Biotechnologies, Faculte des Sciences, Universite Mohamed Premier, Oujda 60000, Morocco ´ ´ ´ ´ 2 Departement de Biologie, Faculte des Sciences, Universite Mohamed Premier, Oujda 60000, Morocco ´ ´ ´ 3 Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5S 1A8 4 Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada M5S 1A8 5 Faculte Pluridisciplinaire de Nador, Universite Mohamed Premier, B.P: 300 Selouane 62700, Morocco ´ ´ Correspondence should be addressed to Mohammed Bellaoui, bmbellaoui@ Received 25 November 2008; Accepted 28 May 2009 Copyright © 2011 Bouchra Qaddouri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The budding yeast Saccharomyces cerevisiae is a valuable system to study cell-cycle regulation, which is defective in cancer cells. Due to the highly conserved nature of the cell-cycle machinery between yeast and humans, yeast studies are directly rele