the cortical and striatal gene expression profile of 100？hz electroacupuncture treatment in 6-hydroxydopamine-induced parkinsons disease model100年的皮层和纹状体基因表达谱赫兹6-hydroxydopamine-induced电针刺激治疗帕金森病模型.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 908439, 14 pages doi:10.1155/2012/908439 Research Article The Cortical and Striatal Gene Expression Profile of 100 Hz Electroacupuncture Treatment in 6-Hydroxydopamine-Induced Parkinson’s Disease Model Li-Rong Huo,1 Xi-Bin Liang,2 Bo Li,1 Jian-Tao Liang,3 Yi He,1 Yan-Jun Jia,1 Jun Jia,1 Xiao-Li Gong,1 Fen Yu,1 and Xiao-Min Wang1 1 Department of Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing 100069, China 2 Department of Neurology, Stanford University, Stanford, CA 94305, USA 3 Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China Correspondence should be addressed to Xiao-Min Wang, xmwang@ Received 30 April 2011; Revised 5 September 2011; Accepted 26 September 2011 Academic Editor: Edwin L. Cooper Copyright © 2012 Li-Rong Huo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Electroacupuncture (EA), especially high-frequency EA, has frequently been used as an alternative therapy for Parkinson disease (PD) and is reportedly effective for alleviating motor symptoms in patients and PD models. However, the molecular mechanism underlying its effectiveness is not completely understood. To implement a full-scale search for the targets of 100 Hz EA, we selected rat models treated with 6-hydroxydopamine into the unilateral MFB, which mimic end-stage PD. High-throughput microarray analysis was then used to uncover the regulated targets in the cortex and str