the effect of metformin on the myocardial tolerance to ischemia-reperfusion injury in the rat model of diabetes mellitus type ii二甲双胍的影响大鼠心肌缺血再灌注损伤的宽容的糖尿病ii型模式.pdfVIP

Hindawi Publishing Corporation Experimental Diabetes Research Volume 2011, Article ID 907496, 5 pages doi:10.1155/2011/907496 Research Article The Effect of Metformin on the Myocardial Tolerance to Ischemia-Reperfusion Injury in the Rat Model of Diabetes Mellitus Type II Ekaterina Kravchuk,1 Elena Grineva,1 Alekber Bairamov,1 Michael Galagudza,2, 3 and Timur Vlasov2, 3 1 Institute of Endocrinology, Almazov Federal Heart, Blood and Endocrinology Centre, Akkuratova Street 2, St. Petersburg 197341, Russia 2 Institute of Experimental Medicine, Almazov Federal Heart, Blood and Endocrinology Centre, Akkuratova Street 2, St. Petersburg 197341, Russia 3 Department of Pathophysiology, St. Petersburg Pavlov State Medical University, Lev Tolstoy Street 6/8, St. Petersburg 197022, Russia Correspondence should be addressed to Michael Galagudza, galagoudza@mail.ru Received 22 March 2011; Accepted 21 April 2011 Academic Editor: N. Cameron Copyright © 2011 Ekaterina Kravchuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In recent years, evidence has been accumulated that metformin, an antidiabetic drug in the biguanide class, in addition to its well-recognized glucose-lowering effect, can also reduce cardiovascular mortality in the patients with type 2 diabetes mellitus (T2DM). Besides, there are a few experimental studies on the possibility of the direct anti-ischemic effect of the drug in both type 1 diabetes mellitus and T2DM. In our study, myocardial tolerance to ischemia in rats with neonatal streptozotocin T2DM was investigated using the model of global ischemia-reperfusion of the i