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Hindawi Publishing Corporation Neural Plasticity Volume 2010, Article ID 870573, 11 pages doi:10.1155/2010/870573 Research Article Synaptic Remodeling in the Dentate Gyrus, CA3, CA1, Subiculum, and Entorhinal Cortex of Mice: Effects of Deprived Rearing and Voluntary Running Andrea T. U. Schaefers,1 Keren Grafen,1 Gertraud Teuchert-Noodt,1 and York Winter1, 2, 3 1 Department of Biology, Bielefeld University, Universitatsstraße 25, 33615 Bielefeld, Germany ¨ 2 Department of Biology, Humboldt University, Berlin, Germany 3 Cluster of Excellence NeuroCure, Charite-Universitatsmedizin Berlin, Berlin, Germany ´ ¨ Correspondence should be addressed to Andrea T. U. Schaefers, aschaefers@uni-bielefeld.de and York Winter, york.winter@charite.de Received 12 December 2009; Revised 6 March 2010; Accepted 7 March 2010 Academic Editor: Michael Stewart Copyright © 2010 Andrea T. U. Schaefers et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hippocampal cell proliferation is strongly increased and synaptic turnover decreased after rearing under social and physical deprivation in gerbils (Meriones unguiculatus). We examined if a similar epigenetic effect of rearing environment on adult neuroplastic responses can be found in mice (Mus musculus). We examined synaptic turnover rates in the dentate gyrus, CA3, CA1, subiculum, and entorhinal cortex. No direct effects of deprived rearing on rates of synaptic turnover were found in any of the studied regions. Howeve