synchrotron ft-ir microspectroscopic analysis of necrotic bone同步加速器红外microspectroscopic坏死骨的分析.pdfVIP

Spectroscopy 21 (2007) 227–234 227 IOS Press Synchrotron FT-IR microspectroscopic analysis of necrotic bone Sevgi Haman Bayarı a,∗, Haluk Utku b , Yuka Ikemoto c , Bülent Celasun d , Mahmut Kömürcü e and Aziz Atik e a Hacettepe University, Faculty of Education, Department of Physics Education, Beytepe 06800, Ankara, Turkey b Institute of Nuclear Sciences, Hacettepe University, Beytepe 06800, Ankara, Turkey c JASRI/SPring-8, Kouto, Sayo, Hyogo 679-5198, Japan d Baskent University, School of Medicine, Department of Pathology, Bahcelievler 06490, Ankara, Turkey e Gulhane Medical Academy, Department of Orthopedic, Etlik 06018, Ankara, Turkey Abstract. Avascular necrosis (osteonecrosis) is a disease that results from the temporary or permanent loss of blood supply to the bone. Synchrotron FT-IR microspectroscopy has been used to study the changes in mineral and matrix content of necrotic bone. FT-IR spectroscopic analysis revealed that in necrotic bone the relative mineral/matrix ratio decreased. Spectroscopic differences were observed between normal and necrotic bones. The noticeable differences may have important implications for analyzing and evaluating death bone. Keywords: Avascular necrosis, necrotic bone, synchrotron, FT-IR microspectroscopy 1. Introduction Avascular necrosis (also called osteonecrosis, aseptic necrosis, or ischemic bone necrosis) is a disease that results from the temporary or permanent loss of blood supply to the bone. When blood supply is cut off, tiny breaks within the bone occurs, the bone tissue dies and the bone collapses. If avascular necrosis occurs near a joint, collapse of the joint surface may occur. Avascular necrosis may occur in any bone, but most commonly occurs in the ends (epiphysis) of long bones such as the femur. It may affect one bone, several bones at one time, or different bones at diffe