synergistic antimycobacterial actions of knowltonia vesicatoria (l.f) sims协同抗knowltonia行为实验(l.f)西姆斯.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 808979, 9 pages doi:10.1155/2012/808979 Research Article Synergistic Antimycobacterial Actions of Knowltonia vesicatoria (L.f) Sims ´ 1 1, 2 ´ ´ 3 1 Antoinette Labuschagne, Ahmed A. Hussein, Benjamın Rodrıguez, and Namrita Lall 1 Department of Plant Science, University of Pretoria, Gauteng Pretoria 0002, South Africa 2 Department of Chemistry of Medicinal Plants, National Research Center, El-Tahrir Street, Dokki, Cairo 12311, Egypt 3 Instituto de Quımica Organica, Consejo Superior de Investigaciones Cientıficas (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain ´ ´ ´ Correspondence should be addressed to Namrita Lall, namrita.lall@up.ac.za Received 18 January 2012; Accepted 19 February 2012 Academic Editor: Victor Kuete ´ Copyright © 2012 Antoinette Labuschagne et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Euclea natalensis A.DC., Knowltonia vesicatoria (L.f) Sims, and Pelargonium sidoides DC. are South African plants traditionally used to treat tuberculosis. Extracts from these plants were used in combination with isoniazid (INH) to investigate the possibility of synergy with respect to antimycobacterial activity. The ethanol extract of K. vesicatoria was subjected to fractionation t