synergistic apoptosis-inducing antileukemic effects of arsenic trioxide and mucuna macrocarpa stem extract in human leukemic cells via a reactive oxygen species-dependent mechanism协同凋亡诱导antileukemic三氧化二砷和黎豆属macrocarpa茎提取物通过活性氧在人类白血病细胞生物机制.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 921430, 14 pages doi:10.1155/2012/921430 Research Article Synergistic Apoptosis-Inducing Antileukemic Effects of Arsenic Trioxide and Mucuna macrocarpa Stem Extract in Human Leukemic Cells via a Reactive Oxygen Species-Dependent Mechanism Kuan-Hung Lu,1 Hui-Ju Lee,2 Min-Li Huang,3 Shang-Chih Lai,4 Yu-Ling Ho,5 Yuan-Shiun Chang,1 and Chin-Wen Chi6, 7 1 Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung 404, Taiwan 2 Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan 3 Center of General Education, National Taipei University of Nursing and Health Sciences, Taipei 112, Taiwan 4 Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan 5 Department of Nursing, Hungkuang University, Taichung 433, Taiwan 6 Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei 112, Taiwan 7 Department and Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan Correspondence should be addressed to Yuan-Shiun Chang, yschang@.tw and Chin-Wen Chi, cwchi@.tw Received 21 January 2011; Revised 10 April 2011; Accepted 17 May 2011 Academic Editor: Alfredo Vannacci Copyright © 2012 Kuan-Hung Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The objective of this study was to examine the potential of enhancing the antileukemic activity of arsenic trioxide (ATO) by combining it with a folk remedy, crude methanolic extract of Mucuna macrocarpa (CMEM