米非司酮联合利凡诺对中期引产孕妇血清泌乳素,雌三醇,孕酮,IGFBP-1及VEGF水平的影响.PDFVIP

HAINAN MEDICAL JOURNAL 《海南医学》2012 年第23 卷第16 期 doi:10.3969/j.issn.1003-6350.2012.16.048 ·检验与临床· 米非司酮联合利凡诺对中期引产孕妇 血清泌乳素、雌三醇、孕酮、IGFBP-1 及VEGF 水平的影响 黄玲玲 (深圳市南山区蛇口人民医院妇产科，广东 深圳 518067) 【摘要】 目的 研究米非司酮联合利凡诺对中期引产孕妇血清泌乳素、雌三醇、孕酮、IGFBP-1及VEGF 水 平影响。方法 选取2010 年2 月至2012 年1月进行中期引产的42 例孕妇，随机分为对照组(利凡诺组) 21 例和观 察组(米非司酮联合利凡诺组) 21 例，对两组孕妇引产前及注射后24 h 、引产后24 h 的血清泌乳素、雌三醇、孕酮、 IGFBP-1及VEGF 水平进行检测及比较。结果 观察组引产后24 h 的血清泌乳素、雌三醇、孕酮及VEGF 水平均 低于对照组，而IGFBP-1高于对照组，差异有统计学意义(P＜0.0)。结论 米非司酮联合利凡诺对中期引产孕妇 血清泌乳素、雌三醇、孕酮、IGFBP-1及VEGF 水平影响大于单用利凡诺，引产效果更佳。 【关键词】 米非司酮；利凡诺；中期引产；泌乳素；雌三醇；孕酮；IGFBP-1；VEGF 【中图分类号】R719.3 【文献标识码】B 【文章编号】 1003—6350（2012 ）16—113—02 Influence of Mifepristone combined with Rivanol on the levels of serum prolactin, estriol, progesterone, IGFBP-1 and VEGF in pregnant women with metaphase induced labor. HUANGLing-ling.DepartmentofGynecologyand Obstetrics,ShekouPeoplesHospitalofNanshanDistrictofShenzhencity,Shenzhen518067,Guangdong,CHINA 【Abstract 】 Objective To study the influence of Mifepristone combined with Rivanol on the levels of serum prolactin, estriol, progesterone, IGFBP-1 and VEGF in pregnant women with metaphase induced labor. Methods For- ty-two pregnant women with metaphase induced labor in our hospital from August 2010 to January 2012 were random- ly divided into the control group (Rivanol group, 21 cases) and the observation group (Mifepristone combined with Rivanol group, 21 cases). Then the levels of serum prolactin, estriol, progesterone, IGFBP-1 and VEGF before in- duced labor, after the injection at 24 hour and after induced labor at 24 hour were detected and compared between the two