盐酸美他环素胶囊（Metacycline Hydrochloride Capsules）.docVIP

盐酸美他环素胶囊（Metacycline Hydrochloride Capsules） Metacycline Hydrochloride Capsules (Metacycline Hydrochloride Capsules) The main ingredients of this product are: hydrochloric acid beauty ring element. Its chemical name is: [4S- (4a, 4a, a, 5A, 5A, a, a, 12a),]-6- methylene -4- (two, a amino), -3,5,10,12,12a - five hydroxy -1, 11- two, oxo -2-, and four benzamide hydrochloride. [traits] This product is capsule. [pharmacology and toxicology] This product belongs to tetracycline antibiotics. Certain tetracycline or oxytetracycline resistant strains can still be sensitive to this product. Many species of Rickettsia, mycoplasma, chlamydia, some atypical mycobacteria and Leptospira are sensitive to this drug, but enterococci are resistant to it. Others such as actinomyces, anthrax, mononucleosis Lester bacteria, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Jerson bacteria were sensitive to the chemicals. This product has certain antibacterial activity against Neisseria gonorrhoeae, but penicillin resistant Neisseria gonorrhoeae is also resistant to cyclosporine. Over the years, due to the widespread use of tetracycline, the clinical common pathogens of severe resistance to the United States, including Staphylococcus, gram positive bacteria and most Enterobacteriaceae bacteria resistance. This product is different from tetracycline, and there are cross resistance among different varieties. The mechanism of action is that the drug can bind to the A position of the bacterial ribosomal 30S subunit, inhibit the growth of peptide chains and affect the synthesis of bacterial proteins. [pharmacokinetics] Oral absorption, single dose of oral 500mg, blood peak concentration (Cmax) is about 2mg/L, blood elimination half-life (T1/2b) 16 hours, protein binding rate of 80%, widely distributed in vivo. The rate of excretion of urine from prototype was about 50% of the dosage, and fecal excretion was only 5% in 72 hours. [indications] (1) this product as the preferred or use drug