非甾体抗炎药（Non steroidal anti-inflammatory drugs）.docVIP

非甾体抗炎药（Non steroidal anti-inflammatory drugs） Prostaglandin and fever, pain and inflammation are closely related, prostaglandins cause inflammation medium, most antipyretic analgesics (except acylation of aniline) can play anti-inflammatory effects by affecting prostaglandin biosynthesis. It focuses on the treatment of rheumatic, rheumatoid arthritis and so on. As the population ages, there will be a greater demand for such drugs. Structure type (I) 3,5- pyrazole, two ketones 1946 found pyrazolidine two quinolones phenylbutazone (phenylbutazone) have good anti-inflammatory and analgesic effect for the treatment of rheumatic arthritis, rheumatoid arthritis, but are toxic to the liver, hematopoietic system, decreasing application. But because it has better uric acid effect, it can treat acute gouty arthritis (effective rate 90%). 1961 found the metabolite of hydroxyl phenylbutazone phenylbutazone (oxyphenbutazone), also have the effect of anti rheumatism and anti-inflammatory, and low toxicity. Sulfinpyrazone (anturan, sulfinpyrazone, sulfinpyrazone) is a derivative of phenylbutazone, almost no anti-inflammatory effect, but have a strong role in the excretion of uric acid (weight of uric acid can strongly inhibit the renal tubular absorption), to promote the excretion of uric acid strength agent. Oral administration for 10 hours, oral administration of 0.5g a day, serum uric acid value dropped by 51%, and anti thrombosis effect. Loading U.S.P and B.P. (two) para amino benzoic acid (acid) The adjacent amino benzoic acid derivative is a non steroidal anti-inflammatory analgesic developed in 60s. A: mefenamic acid (mefenamic acid, mefenamic acid, mefenamic, acid) CLOFENAMIC acid (CLOFENAMIC acid Chlofenamic acid, CLOFENAMIC, acid) Meclofenamic acid sodium (Meclofenamic acid, Meclofenamic acid sodium, Meclofenamic acid, meclofenamate sodium), Finland fluoride the acid (flufenamic acid, flufenamic acid), niflumic acid (niflumic acid, niflumic acid), due to adverse reaction