about shugan and stomach particle of behavioral despair in mice antidepressant effect（shugan和胃颗粒的行为绝望小鼠的抗抑郁效果）.docVIP

About Shugan and stomach particle of behavioral despair in mice antidepressant effect [Abstract] observed the antidepressant effect Liver and stomach particle model of behavioral despair mice. [Methods] Kunming mice were randomly divided into five groups: model group, liver and stomach particle low, medium and high dose groups ( Chinese medicine is low, in the high-dose group, dose 0.25,0.5,1.0 g ?kg-1 ?d-1, the mouse tail suspension and forced swim test immobility time of mice. [Results] Chinese medicine high doses can be significantly shortened mouse tail suspension and swimming immobility time (all P lt;0.05 or P lt;0.01, and was a dose-response relationship. [Conclusion] Liver and stomach particles on behavioral despair model mice with a certain antidepressant effect. [Keywords] Shugan stomach particle pharmacological depression certificate TCM therapy disease model animals mice Chinese medicine has long recognized the relationship between gastrointestinal dysfunction and psychiatric disorders, Shugan and stomach particle is based on Chinese medicine, “liver just dirty, Division emotional” catharsis “,” the hi be reached, evil whisk Yu “, the the stomach main Mizutani receiving and compost and gut the” conduction “, as well as the physiological and pathological characteristics between the liver and stomach, comprehensive clinical experience [1] developed from traditional Chinese medicine. pharmacodynamic The experiments showed that this formulation has the exact promote gastrointestinal motility [2], hypnosis [2] and anti sweep Jue [3] the role of the experimental observation of the antidepressant effect of the party on the the experimental sexual behavior despair in mice aimed at its effect and mechanism of a preliminary study of the treatment of depression are reported below. 1 Data Of 1.1 animals SPF Kunming mice, male, body weight (20 + -2) g the the feeding room temperature (22 + -2) ?C, provided by the Guangdong Medical Laboratory A