analysis of local anesthetic efficacy characteristics（局部麻醉功效特点的分析）.docVIP

Analysis of local anesthetic efficacy characteristics [Abstract] Local anesthetics (local anesthetics) are a class can reversibly block nerve impulse generation and conduction in nerve tissue or nerve tissue in the adjacent area when used, so that the temporary site of nerve feeling, motor and autonomic nerve function of the drug disappear by anesthesia effectiveness, onset time, duration of action and feeling / movement differences in local anesthetic block of the clinical efficacy characteristics. [Keywords:] local anesthetic efficacy characteristics Local anesthesia and regional anesthesia techniques require the use of local anesthetics. Local anesthetics (local anesthetics) are a class can reversibly block nerve impulse generation and conduction in nerve tissue or nerve tissue in the vicinity of the area used to make appear on the site of nerve transient sensory, motor and autonomic nerve function lost drugs. Clinical pharmacology of local anesthetics of the important features, including efficacy, speed of onset, duration of anesthesia, sensory-motor block differences, etc. As mentioned above, the pharmacological characteristics of local anesthetics is determined by its molecular structure and physicochemical characteristics of the decision . (A) the effectiveness of anesthesia Local anesthetic molecules across the membrane of the nerve, and part of Na + channels with hydrophobic (fat soluble) sites play a role in the combination, so that the hydrophobic (lipophilic) is endogenous major determinant of the effectiveness of anesthesia, but anesthetic performance and hydrophobic (fat soluble) the relationship between, not as isolated single nerve from the experimental results as accurate, for example, by a single root for Cain in vitro efficacy than the small nerves in the piperazine Cain is strong, but the actual in vivo conditions than small ropivacaine weak performance. This in vivo and in vitro may be related to differences between the