analysis of serum tgf-βl levels and coronary heart disease clinical relationship（分析血清tgf-βl水平和冠心病的临床关系）.docVIP

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analysis of serum tgf-βl levels and coronary heart disease clinical relationship（分析血清tgf-βl水平和冠心病的临床关系）.doc

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analysis of serum tgf-βl levels and coronary heart disease clinical relationship（分析血清tgf-βl水平和冠心病的临床关系）

Analysis of serum TGF-βl levels and coronary heart disease clinical relationship [Abstract] Objective To study the coronary heart disease (of CHD patients with different clinical forms of serum transforming growth factor beta1 (TGF-β1 level and combined with selective coronary angiography analysis of the results to discuss it with the degree of coronary atherosclerotic plaques and stability relations, in order to study the role of TGF-β1 in the pathogenesis of CHD. my inpatient patients with CHD, 72 cases, the clinical symptoms of 44 cases divided into subgroups with acute coronary syndrome (ACS), stable heart colic (SAP28 cases and confirmed by coronary angiography (CAG) in the control group (n = 15), and conventional coronary angiography to exclude coronary artery disease. measured by ELISA in serum TGF-β1 levels. component CHD CAG surgery into three subgroups: single-vessel disease, double vessel disease and triple vessel disease, left main disease is classified as a double vessel disease subgroup. determine the site of vascular stenosis by visual stenosisgt; = 50% of lesions of coronary count. application of the standards of the SYNTAX score (use to download the from SYNTAX official website of the SYNTAX score calculation results in patients with CHD Serum TGF-β1 water were significantly lower than the control group, were 21012.3 + -13704.1 pg / ml 52120.6 + -27424.0 pg / ml. (P lt;0.05.ACS average serum TGF-β1 in water was significantly lower than the SAP group, 29695.0 + -20561.3 pg / ml 21012.3 + -13704.1 pg / ml of the difference was significant (P lt;0.05) in patients with CHD serum TGF- β1 and coronary artery score, lesion coronary count was negatively correlated with serum TGF-β1 concentration is reduced accordingly, coronary artery score, lesion coronary value corresponding increase in the difference was significant. Conclusions The results of clinical trials tendency Serum TGF-β1 in patients with CHD to the protective effect of serum TGF-β1 is conduciv