a portable and power-free micro？uidic device for rapid and sensitive lead (pb2+) detection便携式和优点微 uidic设备快速和敏感的铅(pb2 +)检测.pdfVIP

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a portable and power-free micro？uidic device for rapid and sensitive lead (pb2+) detection便携式和优点微 uidic设备快速和敏感的铅(pb2 +)检测.pdf

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aportableandpower-freemicro？uidicdeviceforrapidandsensitivelead(pb2)detection便携式和优点微uidic设备快速和敏感的铅(pb2)检测

Sensors 2012, 12, 9467-9475; doi:10.3390/s120709467 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Article A Portable and Power-Free Microﬂuidic Device for Rapid and Sensitive Lead (Pb2+) Detection Chunhui Fan 1,2, Shijiang He 2, Gang Liu 3, Lianhui Wang 1,* and Shiping Song 2,* 1 Laboratory of Advanced Materials, Fudan University, 2205 Songhu Road, Shanghai 200438, China; E-Mail: 09213010009@ 2 Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China; E-Mail: heshijiang@ 3 Shanghai Institute of Measurement and Testing Technology, Shanghai 201203, China; E-Mail: liug@ * Authors to whom correspondence should be addressed; E-Mails: wlhui@ (L.W.); songshiping@ (S.S.); Tel.: +86-21-3919-4065 (S.S.); Fax: +86-21-3919-4702 (S.S.). Received: 29 May 2012; in revised form: 6 June 2012 / Accepted: 2 July 2012 / Published: 10 July 2012 Abstract: A portable and power-free microﬂuidic device was designed for rapid and sensitive detection of lead (Pb2+). 11-mercaptoundecanoic acid (MUA)-functionalized gold nanoparticles (MUA-AuNPs) aggregated in the presence of Pb2+ for the chelation mechanism. When we performed this analysis on a polydimethylsiloxane (PDMS) microfluidic chip, the aggregations deposited onto the surface of chip and formed dark lines along the laminar flows in the zigzag microchannels. This visual result can be observed by the naked eye through a microscope or just a drop of water as