acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patientsacetazolamide-mediated强离子减少差异占纠正危重患者代谢性碱中毒.pdfVIP

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acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patientsacetazolamide-mediated强离子减少差异占纠正危重患者代谢性碱中毒.pdf

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acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patientsacetazolamide-mediated强离子减少差异占纠正危重患者代谢性碱中毒

Available online /content/10/1/R14 Vol 10 No 1 Open Access Research Acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patients 1 1 2 1 Miriam Moviat , Peter Pickkers , Peter HJ van der Voort and Johannes G van der Hoeven 1Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands 2Department of Intensive Care Medicine, Medical Centre Leeuwarden Corresponding author: Peter Pickkers, p.pickkers@ic.umcn.nl Received: 22 Aug 2005 Accepted: 14 Dec 2005 Published: 9 Jan 2006 Critical Care 2006, 10:R14 (doi:10.1186/cc3970) This article is online at: /content/10/1/R14 © 2006 Moviat et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Metabolic alkalosis is a commonly encountered Results After a single administration of acetazolamide, acid–base derangement in the intensive care unit. Treatment correction of serum pH (from 7.49 ± 0.01 to 7.46 ± 0.01; P = with the carbonic anhydrase inhibitor acetazolamide is indicated 0.001) was maximal at 24 hours and sustained during the period in selected cases. According to the quantitative approach of observation. The parallel decrease in partial carbon dioxide described by Stewart, correction of serum pH due to carbonic tension was not significant (from 5.7 ± 0.2 to 5.3 ± 0.2 kPa;