hcv infection igg - igm（丙肝病毒感染免疫球蛋白g - igm）.docVIP

HCV infection IgG / IgM [Keywords] immune disorder Abstract: Objective To investigate the the IgG / IgMTCIC in the in vivo significance of HCV infection. The trapping method ELISA goat IgG anti-human IgG as coating antibody, HRP anti-human IgM goat IgG instructions antibody detected 80 cases of HCV infection and 30 healthy human body IgG / IgMTCIC level results HCV infection group IgG / IgMTCIC level significantly higher than the healthy control group (P lt;0.01, further comparison of the relationship with ALT and BT of IgG / IgMTCIC with both non-significant relationship (Pgt; 0.05). conclusion the IgG / IgMTCIC not directly pathological processes involved in liver damage, but it is an important indication of the hepatitis C patients with humoral immune disorders. Keywords: HCV, IgG / IgMTCIC; ELISA, immune disorders Abstract: Objective To preliminarily elucidate the significance of IgG / IgMTCIC in HCVinfected individuals. Methods Coated with goat IgG aimed to human IgG, and then detected by HRPlabeled goat IgG aimed to human IgM, a capture ELISA method was established to examine the circulating immune complexes composed of IgG and IgM (ie IgG / IgMTCIC) in HCVinfected individuals (80 cases) and healthy individuals (30 cases). Results The level of IgG / IgMTCIC in HCVinfected individuals was obviously higher than that in the control group (healthy individuals). In addition, there was not an obvious correlation between the level of IgG / IgMTCIC and ALT or BT in the serum of HCV infected individuals. Conclusion It was suggested that IgG / IgMTCIC did not participate in the damage of liver, whereas it might be an important indication that reflected the disordered status of humoral immune response. Keywords:: hepatitis C virus (HCV), IgG / IgMTCIC, ELISA, immunologic derangement Since bispecific circulating immune complexes (twocomponentdetermined circulating immune complexes, TCIC) concept [], an endless stream of relevant reports to date, stu