聚乙二醇修饰的抗粘附多肽YIGSR对肝癌细胞粘附能力的作用.pdfVIP

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聚乙二醇修饰的抗粘附多肽YIGSR对肝癌细胞粘附能力的作用.pdf

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聚乙二醇修饰的抗粘附多肽YIGSR对肝癌细胞粘附能力的作用

目录中文摘要英文摘要 ·······················································································… …3 引言 ·····························································································… …5 第一部分抗粘附多肤 Y IG SR 的聚乙二醇化去聚乙二醇化研究 ···············… …7 材料与方法 ····················································································… …7 结果 ·····························································································… … 13 讨论 ·····························································································… … 16 结论 ·····························································································… … 18 参考文献 ·······················································································… … 19 第二部分 P E G 一Y IG SR 的体外粘附抑制作用及大鼠血清降解研究 ············… …20 材料与方法 ····················································································… …20 结果 ·····························································································… …27 讨论 ·····························································································… …31 结论 ·····························································································… …犯参考文献 ·······················································································… …33 综述层粘连蛋白的研究进展 ····························································… …35 附录已发表文章 ···········································································… …45 致谢 ·····························································································… …56 复旦大学硕士学位论文聚乙二醇修饰的抗粘附多肤 Y IG SR 对肝癌细胞粘附能力的影响中文摘要目的抗粘附多肤 Y IG SR (酪一异亮一甘一丝一精 ) 对肝癌细胞有抗粘附作用，但因其分子小、半衰期短，限制了实际应用。本研究拟用 P E G 修