胃肠道恶性肿瘤及非恶性肿瘤老年患者认知功能的 研究.pdfVIP

福建医科大学硕士学位论文 福建医科大学硕士学位论文 目 录 中文摘要„„„„„„„„„„„„„„„„„„„„„„„„1 英文摘要„„„„„„„„„„„„„„„„„„„„„„„„2 前 言„„„„„„„„„„„„„„„„„„„„„„„„3 资料与方法„„„„„„„„„„„„„„„„„„„„„„„4 结 果„„„„„„„„„„„„„„„„„„„„„„„„7 讨 论„„„„„„„„„„„„„„„„„„„„„„„„11 结 论„„„„„„„„„„„„„„„„„„„„„„„„16 参考文献„„„„„„„„„„„„„„„„„„„„„„„„17 综 述„„„„„„„„„„„„„„„„„„„„„„„„21 参考文献„„„„„„„„„„„„„„„„„„„„„„„„26 致 谢„„„„„„„„„„„„„„„„„„„„„„„„30 福建医科大学硕士学位论文 中文摘要 目的 对比分析老年胃肠道恶性肿瘤与非恶性肿瘤老患者认知功能的差 别，为临床的进一步研究防治术后认知功能障碍提供前期研究结果。 方法 采用听觉词语学习测验(AVLT)和画钟实验（CDT ）两种神经心理测 验方法，对2014 年 11 月至2015 年 1 月期间在福建医科大学附属协和医院住院 的73 名60 岁至80 岁的胃肠道恶性肿瘤老年患者 （A 组）与47 名同年龄段的 非恶性肿瘤老年患者（B 组）的认知功能进行评估，并记录患者的临床资料，包 括病案号、年龄、性别、受教育程度、内科合并症等，两组患者的基本资料以及 评估结果根据正态性检验结果分别利用独立样本t 检验、卡方检验、秩和检验和 R*C 表资料的卡方检验进行统计学分析，进一步比较二者间的差异。 结果 A 、B 两组病例在年龄、性别组成、受教育程度及内科合并症等方 面的差异无统计学意义（P0.05 ）；A 组的短时刻记忆（AVLT-1、AVLT-2 、AVLT-3、 AVLT-I ）、短延迟回忆（AVLT-4 ）与AVLT 总分明显低于B 组，A 组的认知功 能障碍发生率（43.83% ）明显高于B 组（25.53% ）,差异均有统计学意义（P0.05 ）， 但A 组患者的长延迟记忆得分（AVLT-5 ）、AVLT-E 、AVLT 再认及CDT 得分与 B 组的差异无统计学意义（P0.05 ）。 结论 胃肠道恶性肿瘤患者认知功能损害较非恶性肿瘤患者明显，且认知 损害主要表现在短时刻记忆和短延迟回忆。 关键词 胃肠道恶性肿瘤 听觉词语学习测验(AVLT) 画钟试验(CDT) 记 忆 认知功能 1 福建医科大学硕士学位论文 Abstract Objective To compare the difference on cognitive function in old patients suffering from the gastrointestinal malignant tumors and the non-malignant tumor diseases,and the preliminary findings are useful for the clinical prevention of postoperative cognitive dysfunction for further clinical studies and treatment. Methods From November 2014 to January 2015, 73 patients suffering from the gastrointestinal malignant tumors (group A)and 47 patients suffering from the