原创力文档a comparative study of two folate-conjugated gold nanoparticles for cancer nanotechnology applications比较研究两个folate-conjugated金纳米粒子对癌症纳米技术的应用程序.pdfVIP
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a comparative study of two folate-conjugated gold nanoparticles for cancer nanotechnology applications比较研究两个folate-conjugated金纳米粒子对癌症纳米技术的应用程序
Cancers 2010, 2, 1911-1928; doi:10.3390/cancers2041911
OPEN ACCESS
cancers
ISSN 2072-6694
/journal/cancers
Review
A Comparative Study of Two Folate-Conjugated Gold
Nanoparticles for Cancer Nanotechnology Applications
G. Ali Mansoori 1,*, Kenneth S. Brandenburg 1 and Ali Shakeri-Zadeh 2
1 Department of Bioengineering, University of Illinois at Chicago, 851 S. Morgan St. (MC 063),
Chicago, IL 60607, USA; E-Mail: kbrand@
2 Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran;
E-Mail: shakeri2005@
* Author to whom correspondence should be addressed; E-Mail: mansoori@;
Tel.: +1-312-996-5592.
Received: 29 October 2010; in revised form: 10 November 2010 / Accepted: 11 November 2010 /
Published: 18 November 2010
Abstract: We report a comparative study of synthesis, characteristics and in vitro tests of
two folate-conjugated gold nanoparticles (AuNP) differing in linkers and AuNP sizes for
selective targeting of folate-receptor positive cancerous cells. The linkers chosen were
4-aminothiophenol (4Atp) and 6-mercapto-1-hexanol (MH) with nanoconjugate products
named Folate-4Atp-AuNP and Folate-MH-AuNP . We report the folate-receptor tissue
distribution and its endocytosis for targeted nanotechnology. Comparison of the two
nanoconjugates’ syntheses and characterization is also reported, including materials and
methods of synthesis, UV-visible absorption spectroscopic measurements, Four
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