a cytoplasmic complex mediates specific mrna recognition and localization in yeast细胞质复杂介导特定的信使rna识别和定位在酵母.pdfVIP
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a cytoplasmic complex mediates specific mrna recognition and localization in yeast细胞质复杂介导特定的信使rna识别和定位在酵母
A Cytoplasmic Complex Mediates Specific mRNA
Recognition and Localization in Yeast
¨ 1,2. 1,2. 2 3 2¤
Marisa Muller , Roland Gerhard Heym , Andreas Mayer , Katharina Kramer , Maria Schmid ,
2,4 3 2,5 1,2
Patrick Cramer , Henning Urlaub , Ralf-Peter Jansen , Dierk Niessing *
¨ ¨
1 Institute of Structural Biology, Helmholtz Zentrum Munchen–German Research Center for Environmental Health, Munchen, Germany, 2 Gene Center and Department
¨
of Biochemistry, Ludwig-Maximilians-University, Munchen, Germany, 3 Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry,
¨ ¨ ¨ ¨
Gottingen, Germany, 4 Center for Integrated Protein Science CIPSM, Munchen, Germany, 5 Interfaculty Institute for Biochemistry, University of Tubingen, Tubingen,
Germany
Abstract
In eukaryotes, hundreds of mRNAs are localized by specialized transport complexes. For localization, transcripts are
recognized by RNA-binding proteins and incorporated into motor-containing messenger ribonucleoprotein particles
(mRNPs). To date, the molecular assembly of such mRNPs is not well understood a
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