a diverse population of cryptococcus gattii molecular type vgiii in southern californian hivaids patients不同类型的隐球菌gattii分子类型vgiii加州南部的条件.pdfVIP
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a diverse population of cryptococcus gattii molecular type vgiii in southern californian hivaids patients不同类型的隐球菌gattii分子类型vgiii加州南部的条件
A Diverse Population of Cryptococcus gattii Molecular
Type VGIII in Southern Californian HIV/AIDS Patients
1.¤ 1. 2. 1 3 4
Edmond J. Byrnes III , Wenjun Li , Ping Ren , Yonathan Lewit , Kerstin Voelz , James A. Fraser ,
1,5 3 2 2 1
Fred S. Dietrich , Robin C. May , Sudha Chatuverdi , Vishnu Chatuverdi , Joseph Heitman *
1 Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, 2 Mycology Laboratory,
Wadsworth Center, Albany, New York, United States of America, 3 School of Biosciences, University of Birmingham, Birmingham, United Kingdom, 4 Centre for Infectious
Disease Research, Department of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia, 5 Institute for Genome Sciences and Policy, Duke
University Medical Center, Durham, North Carolina, United States of America
Abstract
Cryptococcus gattii infections in southern California have been reported in patients with HIV/AIDS. In this study, we
examined the molecular epidemiology, population structure, and virulence attributes of isolates collected from HIV/AIDS
patients in Los Angeles County, California. We show that these isolates consist almost exclusively of VGIII molecular type, in
contrast to the VGII molecular type isolates causing the North American Pacific Northwest outbreak. The global VGIII
population structure can be divided into two molecular groups, VGIIIa and VGIIIb. Isolates from the Californian patients are
virulent in murine and macrophage models
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