原创力文档a methodological approach to assessing the health impact of environmental chemical mixtures pcbs and hypertension in the national health and nutrition examination survey方法论的方法来评估环境健康影响的化学混合物多氯联苯和高血压在全国健康和营养调查.pdfVIP
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a methodological approach to assessing the health impact of environmental chemical mixtures pcbs and hypertension in the national health and nutrition examination survey方法论的方法来评估环境健康影响的化学混合物多氯联苯和高血压在全国健康和营养调查
Int. J. Environ. Res. Public Health 2011, 8, 4220-4237; doi:10.3390/ijerph8114220
OPEN ACCESS
International Journal of
Environmental Research and
Public Health
ISSN 1660-4601
/journal/ijerph
Article
A Methodological Approach to Assessing the Health Impact of
Environmental Chemical Mixtures: PCBs and Hypertension in
the National Health and Nutrition Examination Survey
Krista L. Yorita Christensen * and Paul White
US Environmental Protection Agency, Mailstop 8623P, 1200 Pennsylvania Ave NW, Washington,
DC 20460, USA; E-Mail: white.paul@
* Author to whom correspondence should be addressed; E-Mail: christensen.krista@;
Tel.: +1-703-347-0185; Fax: + 1-703-347-8692.
Received: 8 September 2011; in revised form: 19 October 2011 / Accepted: 2 November 2011 /
Published: 9 November 2011
Abstract: We describe an approach to examine the association between exposure to
chemical mixtures and a health outcome, using as our case study polychlorinated biphenyls
(PCBs) and hypertension. The association between serum PCB and hypertension among
participants in the 1999–2004 National Health and Nutrition Examination Survey was
examined. First, unconditional multivariate logistic regression was used to estimate odds
ratios and associated 95% confidence intervals. Next, correlation and multicollinear
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