三七皂甙Rg1纹状体内注射对帕金森病模型大鼠免疫炎症损伤的拮抗效应.PDFVIP

张林波等　三七皂甙 Rg1 纹状体内注射对帕金森病模型大鼠免疫炎症损伤的拮抗效应　第 2 期 1·21 · ·中医中药与免疫· 三七皂甙 Rg1 纹状体内注射对帕金森病模型大鼠 免疫炎症损伤的拮抗效应 ( ) 张林波 　杨贵贞 　 吉林大学基础医学院免疫学教研室 ,长春 130021 　　中国图书分类号 　R742. 5 　　文献标识码 　A 　　文章编号 　1000484X( 2004) [摘 　要] 　目的 :探讨三七皂甙 Rg1 对帕金森病模型大鼠免疫炎症损伤的拮抗效应。方法 :建立帕金森病大鼠模型 ,采用 三七皂甙 Rg1 纹状体内注射 ,检测处理后大鼠的神经行为、纹状体内炎性因子含量变化及脾细胞增殖反应。结果 :三七皂甙 α β Rg1 可明显减少模型大鼠的神经旋转行为 ,降低纹状体损毁侧 TNF 、IL1 和 IL6 含量 , 同时对脾细胞有增殖效应。结论 :三 七皂甙 Rg1 可调整机体的免疫功能 ,降低免疫炎性反应对多巴胺能神经元的损伤。 [ 关键词] 　帕金森病;三七皂甙 ;炎性反应 ;旋转行为 The antagonistic effect of notoginsenosideRg1 injected in striatum on immunoin flammatory injury in rat model of Parkinson ’s disease ZHANG LinBo , YANG GuiZhen . Department of Immunology , School of Basic Medicine , Jilin University , Changchun 130021 , China [ Abstract ] 　Objective :To study the effect of notoginsenosideRg1 on immunoinflammatory injury in rat model of Parkinson′s disease. Methods :The rat model of Parkinson′s disease was established and treated with notoginsenosideRg1 by injecting in the striatum. The change of ro tational behavior ,levels cytokines in striatum and splenocyte proliferation were measured. Results :After treatment with notoginsenosideRg1 the ro α β tational behavior and levels of TNF ,IL1 ,IL6 were decreased. The splenocyte proliferation was increased. Conclusion :NotoginsenosideRg1 can regulate the immunological function and reduce the pathological injury to dopaminergic neuron caused by immunoinflammatory reaction. [ Key words ] 　Parkinson’s disease ;NotoginsenosideRg1 ; Immunoinflammatory reactions ;Rotational behavior α β 　　帕金森病是一种常见于中老年人的中枢神经系 TNF 、IL1 和 IL6 含量及脾细