原创力文档receptor-induced dilatation in the systemic and intrarenal adaptation to pregnancy in ratsreceptor-induced扩张在系统性和intrarenal适应怀孕的老鼠.pdfVIP
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receptor-induced dilatation in the systemic and intrarenal adaptation to pregnancy in ratsreceptor-induced扩张在系统性和intrarenal适应怀孕的老鼠
Receptor-Induced Dilatation in the Systemic and
Intrarenal Adaptation to Pregnancy in Rats
1 2 1 3 1
Vanessa M. Ferreira , Thiago S. Gomes , Luciana A. Reis , Alice T. Ferreira , Clara V. Razvickas , Nestor
1 1
Schor , Mirian A. Boim *
˜ ˜ ˜ ˜ ˜
1 Department of Medicine, Renal Division, Federal University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil, 2 Department of Pathology, Federal University of Sao Paulo, Sao
˜ ˜ ˜ ˜
Paulo, Sao Paulo, Brazil, 3 Department of Biophysics, Federal University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
Abstract
Normal pregnancy is associated with systemic and intrarenal vasodilatation resulting in an increased glomerular filtration
rate. This adaptive response occurs in spite of elevated circulating levels of angiotensin II (Ang II). In the present study, we
evaluated the potential mechanisms responsible for this adaptation. The reactivity of the mesangial cells (MCs) cultured
from 14-day-pregnant rats to Ang II was measured through changes in the intracellular calcium concentration ([Cai]). The
expression levels of inducible nitric oxide synthase (iNOS), the Ang II-induced vasodilatation receptor AT2, and the relaxin
(LGR7) receptor were evaluated in cultured MCs and in the aorta, renal artery and kidney cortex by real time-PCR. The
intrarenal distribution of LGR7 was further analyzed by immunohistochemistry. The MCs displaye
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