rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse有节奏的瘦素需要从生理不同步的喂养的老鼠体重增加.pdfVIP

Rhythmic Leptin Is Required for Weight Gain from Circadian Desynchronized Feeding in the Mouse Deanna Marie Arble, Martha Hotz Vitaterna, Fred W. Turek* Northwestern University, Center for Sleep and Circadian Biology, Evanston, Illinois, United States of America Abstract The neuroendocrine and metabolic effects of leptin have been extensively researched since the discovery, and the later identification, of the leptin gene mutated within the ob/ob mouse. Leptin is required for optimal health in a number of physiological systems (e.g. fertility, bone density, body weight regulation). Despite the extensive leptin literature and many observations of leptin’s cyclical pattern over the 24-hour day, few studies have specifically examined how the circadian rhythm of leptin may be essential to leptin signaling and health. Here we present data indicating that a rhythmic leptin profile (e.g. 1 peak every 24 hours) leads to excessive weight gain during desynchronized feeding whereas non-rhythmic leptin provided in a continuous manner does not lead to excessive body weight gain under similar feeding conditions. This study suggests that feeding time can interact with leptin’s endogenous rhythm to influence metabolic signals, specifically leading to excessive body weight gains during ‘wrongly’ timed feeding. Citation: Arble DM, Vitaterna MH, Turek FW (2011) Rhythmic Leptin Is Required for Weight Gain from Circadian Desynchronized Feeding in the Mouse. PLoS ONE 6(9): e25079. doi:10.1371/journal.pone.0025079 Editor: Shin Yamazaki, Vanderbilt University, United States of America Received May 23, 2011; Accepted August 24, 2011; Published September 19, 2011 Copyright: 2011 Arble et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any m