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sialoadhesin expressed on ifn-induced monocytes binds hiv-1 and enhances infectivitysialoadhesin ifn-induced单核细胞结合hiv - 1表达,提高传染性
Sialoadhesin Expressed on IFN-Induced Monocytes Binds
HIV-1 and Enhances Infectivity
1 1 1 1,2
Hans Rempel , Cyrus Calosing , Bing Sun , Lynn Pulliam *
1 Department of Laboratory Medicine at the Veterans Affairs Medical Center, San Francisco, California, United States of America, 2 University of California San Francisco,
San Francisco, California, United States of America
Abstract
Background: HIV-1 infection dysregulates the immune system and alters gene expression in circulating monocytes.
Differential gene expression analysis of CD14+ monocytes from subjects infected with HIV-1 revealed increased expression
of sialoadhesin (Sn, CD169, Siglec 1), a cell adhesion molecule first described in a subset of macrophages activated in
chronic inflammatory diseases.
Methodology/Principal Findings: We analyzed sialoadhesin expression on CD14+ monocytes by flow cytometry and found
significantly higher expression in subjects with elevated viral loads compared to subjects with undetectable viral loads. In
cultured CD14+ monocytes isolated from healthy individuals, sialoadhesin expression was induced by interferon-a and
interferon-c but not tumor necrosis factor-a. Using a stringent binding assay, sialoadhesin-expressing monocytes adsorbed
HIV-1 through interaction with the sialic acid residues on the viral envelope glycoprotein gp120. Furthermore, monocytes
expressing sialoadhesin facilitated HIV-1 trans infection of permissive cells, which occurred in the absence of monocyte self-
infection.
Conclusions/Significance: Increased sialoadhesin expression on CD14+ monocytes occurred in response to HIV-1 infection
with maximum expression associated with high viral load. We show that interferons induce
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