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sialic acid utilisation and synthesis in the neonatal rat revisited唾液酸的利用率和合成新生儿鼠再现
Sialic Acid Utilisation and Synthesis in the Neonatal Rat
Revisited
´ ´
Peter I. Duncan*, Frederic Raymond, Andreas Fuerholz, Norbert Sprenger*
´
Nestle Research Center, Vers-chez-les-Blanc, Lausanne, Switzerland
Abstract
Background: Milk is the sole source of nutrients for neonatal mammals and is generally considered to have co-evolved with
the developmental needs of the suckling newborn. One evolutionary conserved constituent of milk and present on many
glycoconjugates is sialic acid. The brain and colon are major sites of sialic acid display and together with the liver also of
synthesis.
Methodology/Principal Findings: In this study we examined in rats the relationship between the sialic acid content of milk
and the uptake, utilization and synthesis of sialic acid in suckling pups. In rat milk sialic acid was found primarily as
39sialyllactose and at highest levels between 3 and 10 days postpartum and that decreased towards weaning. In the liver of
suckling pups sialic acid synthesis paralleled the increase in milk sialic acid reaching and keeping maximum activity from
postnatal day 5 onwards. In the colon, gene expression profiles suggested that a switch from sialic acid uptake and
catabolism towards sialic acid synthesis and utilization occurred that mirrored the change of sialic acid in milk from high to
low expression. In brain sialic acid related gene expression profiles did not change to any great extent during the suckling
period.
Conclusions/Significance: Our results support the views that (i) when milk sialic acid levels are high, in the colon this sialic
acid is catabolized to GlcNAc that in turn may be used as such or used as substrate for sialic acid synthesis and (ii) when milk
sialic acid levels are low the endogenous sialic acid synthetic machinery in colon is activat
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