silencing, positive selection and parallel evolution busy history of primate cytochromes c沉默,积极的选择和并行进化繁忙的灵长类动物的细胞色素c的历史.pdfVIP

Silencing, Positive Selection and Parallel Evolution: Busy History of Primate Cytochromes c 1,2 1,3 4 1 1,5 1,2 Denis Pierron , Juan C. Opazo , Margit Heiske , Zack Papper , Monica Uddin , Gopi Chand , 1,2,6 1,2 1,7{ 1 Derek E. Wildman , Roberto Romero , Morris Goodman , Lawrence I. Grossman * 1 Center for Molecular Medicine and Genetics, Wayne State University, School of Medicine, Detroit, Michigan, United States of America, 2 Perinatology Research Branch, National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland and Detroit, Michigan, United States of America, 3 Instituto de ´ Ecologia y Evolucion, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile, 4 Laboratoire de Physiopathologie Mitochondriale, INSERM, Universite Victor Segalen Bordeaux 2, Bordeaux, France, 5 School of Public Health, The University of Michigan, Ann Arbor, Michigan, United States of America, 6 Department Of Obstetrics and Gynecology, Wayne State University, School of Medicine, Detroit, Michigan, United States of America, 7 Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, Michigan, United States of America Abstract Cytochrome c (cyt c) participates in two crucial cellular processes, energy production and apoptosis, and unsurprisingly is a highly conserved protein. However, previ