stromal-to-epithelial transition during postpartum endometrial regeneration在产后子宫内膜再生stromal-to-epithelial过渡.pdfVIP

Stromal-to-Epithelial Transition during Postpartum Endometrial Regeneration Cheng-Chiu Huang1,2,3, Grant D. Orvis2,4, Ying Wang2,3, Richard R. Behringer1,2,3,4* 1 Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America, 2 Department of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America, 3 Center for Stem Cell and Developmental Biology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America, 4 Program in Genes and Development, University of Texas, Graduate School of Biomedical Sciences at Houston, Houston, Texas, United States of America Abstract Endometrium is the inner lining of the uterus which is composed of epithelial and stromal tissue compartments enclosed by the two smooth muscle layers of the myometrium. In women, much of the endometrium is shed and regenerated each month during the menstrual cycle. Endometrial regeneration also occurs after parturition. The cellular mechanisms that regulate endometrial regeneration are still poorly understood. Using genetic fate-mapping in the mouse, we found that the epithelial compartment of the endometrium maintains its epithelial identity during the estrous cycle and postpartum regeneration. However, whereas the stromal compartment maintains its identity during homeostatic cycling, after parturition a subset of stromal cells differentiates into epithelium that is subsequently maintained. These findings identify potential progenitor cells within the endometrial stromal compartment that produce long-term epithelial tissue during postpartum endometrial regeneration. Citation: Huang C-C, Orvis GD, Wang Y, Behringer RR (2012) Stromal-to-Epithelial Transition during Postpartum Endometrial Regeneration. PLoS ONE 7(8): e44285