结缔组织病和风湿性疾病（Connective tissue disease and rheumatic diseases）.docVIP

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结缔组织病和风湿性疾病（Connective tissue disease and rheumatic diseases）.doc

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结缔组织病和风湿性疾病（Connective tissue disease and rheumatic diseases）

结缔组织病和风湿性疾病（Connective tissue disease and rheumatic diseases） Section 1 rheumatoid arthritis Rheumatoid arthritis (rheumatoid arthritis) is a chronic inflammatory disease characterized by the majority of small joints around the symmetry, which can be accompanied by systemic lesions outside the joint. The pathology is synovitis of the joint, which involves joint deformity when it involves cartilage and bone. Rheumatoid factor was present in the patients serum. It is an autoimmune disease. (1) cause of disease The cause is unknown. May be related to the following factors. 1. infection factor Mycoplasma, mycobacteria, enteric bacteria, EB, HTLV - I and other retroviruses have been suspected of causing the disease, but no evidence has been found. 2. susceptibility The susceptibility of the disease is related to the genetic basis, that is, class II HLA. (two) pathogenesis The occurrence and stretches of rheumatoid arthritis not more pathogens and genetic interaction results. The following assumptions can be used to illustrate the interaction between the two: HLA may act as a receptor for certain pathogens; The antigen fragment of pathogen combines with amino acid of HLA molecule; The role of molecular simulation, which is associated with HLA molecules and pathogens have similar gene structure, such as HLA and DR4 and some subtypes of EB virus capsid antigen (gP110) is a section of the same amino acids, the antibody response to pathogens into the immune response to the antigen. When the antigen enters the human body first phagocytosed by macrophages or macrophage like cells, digested, concentrated and cell membrane HLA - DR molecules into complex, this complex is the T cell receptor recognition, the lymphocytes were activated, causing a series of immune responses, including activation of B the differentiation of lymphocytes, plasma cells, secretion of immunoglobulin, including rheumatoid factor (rheumatoid factor). Rheumatoid factor is the immunoglobulin IgGFc end of the