两种三联方案根除幽门螺杆菌效价比分析关系.docVIP

两种三联方案根除幽门螺杆菌效价比分析关系 　【摘要】 ［目的］观察奥美拉唑三联疗法与枸橼酸铋钾(CBS)三联疗法根除幽门螺杆菌(Hp)的效果。［方法］胃镜证实的Hp阳性的胃炎患者120例,随机分成奥美拉唑三联组60例枸橼酸铋钾三联组60例,疗程1周，疗程结束4周后用C13-UBT复查Hp,观察Hp根除率；胃镜证实的Hp阳性的消化性溃疡患者90例,随机分成奥美拉唑三联组45例枸橼酸铋钾三联组45例,三联治疗1周，随后分别以奥美拉唑和枸橼酸铋钾治疗6周，疗程结束后4周后复查胃镜,观察Hp根除率、溃疡愈合率。［结果］胃炎患者奥美拉唑组与枸橼酸铋钾组Hp根除率分别为93.33%(56/60)和90%(54/60)，两种根除Hp比较差异无显著性；消化性溃疡患者奥美拉唑组与枸橼酸铋钾组Hp根除率分别为95.56%(43/45)和91.11%(41/45) 比较无显著性差异，溃疡愈合率奥美拉唑组与枸橼酸铋钾组分别为97.78%(44/45)和82.22%(37/45) 比较有显著性差异。［结论］治疗胃炎两种方案效果类似但枸橼酸铋钾方案更价廉；消化性溃疡宜选择奥美拉唑方案。 【关键词】 幽门螺杆菌；慢性胃炎；奥美拉唑；枸橼酸铋钾；三联疗法 　　Effect Price Ratio to Two Plans of Tri-combination Remove H.Pylori Yin Hongwei Hospital Affiliated to Jiangsu University, Zhenjiang(212001) 　　Abstract： ［Objective］To observe the effect of Omerazole and CBS tri-combination therapy on removing Hp. ［Method］ Randomly divide gastritis patients 120 cases with postive Hp into tri-combination group of Omerazole and control group of CBS, both for 1 week. After 4 weeks, use C13-UBT to test Hp, observe the Hp removing rate; divide Hp-positive digestive ulcer patients 90 cases into the groups above 45 in each group; after 1 week of tri-combination therapy, treat with Omerazole and CBS for 6 weeks; retest Hp removing rate 4 weeks after treatment, observe the Hp removing rate and ulcer cure rate. ［Result］ For the gastritis patients, the removing rates were 93.33%(56/60) and 90%(54/60) respectively，there was no marked difference; for the ulcer patients, they were 95.56%(43/45) and 91.11%(41/45) respectively, no difference too; on ulcer cure rates, they were 97.78%(44/45) and 82.22%(37/45) respectively, with marked difference. ［Conclusion］ The two plans treating gastritis are similar to CBS, but cheaper; the Omerazole plan should be chosen for digestive ulcer. 　　Key words：Hp; chronic gastritis; Omerazole; CBS; tri-combination therapy 　　1 资料和方法 　　1.1 一般资料 选择2006年1月至10月本院门诊或住院病人210例，年龄为45±12岁。胃镜确诊Hp阳性慢性胃炎120例，按随机表随机分为奥美拉唑三联组60例(奥美拉唑组),年龄为41±12岁；CBS三联组52例(枸橼酸铋钾组)60例，年龄40±14岁。胃镜确诊Hp阳性消化性溃疡90例，按随机表随机分为奥美拉唑三联组45例(奥美拉唑组)，年龄为4