急性脑梗死患者血C反应蛋白水平及颈动脉粥样硬化关系.doc

急性脑梗死患者血C反应蛋白水平及颈动脉粥样硬化关系 　 作者：吴海琴，张桂莲，张茹，袁海峰，姚丽，王学良，赵英贤 【摘要】 目的 探讨急性脑梗死患者血C反应蛋白(CRP)水平与颈动脉粥样硬化的关系。方法 对52例急性脑梗死患者和30例对照组进行观察。采用速率散射比浊法测定血CRP含量；应用美国Acuson Sequoia 521彩色电脑声像仪检测颈动脉内膜中膜厚度(IMT)，观察颈动脉粥样斑块。结果 急性脑梗死患者血CRP含量、颈动脉IMT和粥样斑块数较对照组明显增加；血CRP水平与临床神经功能缺损评分、吸烟指数、颈动脉IMT及斑块数呈正相关。结论 CRP作为炎性指标可能在促进动脉粥样硬化的发生和发展中起了重要的作用；血CRP水平可作为急性脑梗死患者病情轻重和预后的评价指标。 【关键词】 急性脑梗死；C反应蛋白；动脉粥样硬化；临床神经功能缺损评分 　　The relationship between blood CRP concentration and carotid　atherosis in patients with acute cerebral infarction 　　ABSTRACT: Objective To investigate the relationship between blood Creactive protein (CRP) concentration and carotid atherosis in patients with acute cerebral infarction. Methods A total of 52 patients with acute cerebral infarction and 30 persons as the controls were included in the study. The concentration of CRP in the blood was measured by rate nephelometry and echocardiographic method. Carotid intimamedia thickness (IMT) and carotid plaque were observed by America Acuson Sequoia 521 Computed Sonography. Results The blood CRP concentration, carotid IMT and the number of the carotid pladues were significantly higher in the patients than in the controls. There were positive correlations of the blood CRP concentration with clinical neurological function deficit scale, smoking index, carotid IMT, and number of plaques, respectively. Conclusion CRP is an important index for inflammation at the beginning and progression of atherosis. The blood CRP concentration can be considered as an indicator to evaluate the severity and prognosis of acute cerebral infarction. 　　KEY WORDS: acute cerebral infarction; Creactive protein(CRP); atherosis; clinical neurological function deficit scale 　　动脉粥样硬化是心、脑血管疾病的主要病理基础，而动脉粥样硬化往往伴随慢性炎症过程。C反应蛋白(Creactive protein, CRP)是急性时相反应蛋白之一，是敏感的炎性标志物。CRP升高提示动脉不稳定斑块和血栓的存在，预示发生心脑血管事件的几率增高。本研究观察了52例急性脑梗死患者血CRP含量、颈动脉粥样硬化斑块、颈动脉内膜中膜厚度(intimamedia thickness, IMT)，探讨急性脑梗死患者血CRP含量与颈动脉粥样硬化的关系。 　　1 对象与方法 　　1.1 研究对象 脑梗死组：随机选取2005年6月至2006年5月在本院神经内科住院、病程在1周之内的初发脑梗死患者