盐酸尼卡地平用于全麻预防气管插管反应临床观察.docVIP

盐酸尼卡地平用于全麻预防气管插管反应临床观察 　【摘要】 目的 观察盐酸尼卡地平用于防止气管插管反应的安全性和有效性。方法 将60例患者随机将病人分成3组，即生理盐水对照组（n0）、盐酸尼卡地平0.01 mg/kg组（n1）、盐酸尼卡地平0.02 mg/kg组（n2），每组20例。用DASH3000多功能无创生理监护仪监测血压，ECG，记录基础，麻醉诱导前及气管插管后1、3、5 min的平均动脉压（MAP），心率（HR）。结果 与基础值相比，n1、n2组MAP在使用盐酸尼卡地平后均显著下降，n2组降压效果优于n1组。插管后n1组、n2组 H R有明显增快n2组与n1组之间无明显差别。结论 临床上使用0.01～0.02 mg/kg盐酸卡尼地平预防气管插管引起的升压均为有效剂量。 【关键词】 盐酸尼卡地平 气管插管 　　Abstract：Objective To review the safety and efficacy of Nicardipine Hydrochloride in the prevention of the Endotracheal Intubation Reactions. Methods Retrospective reviews were made to 60 patients who were classified into the normal saline-control group(n0),NicardipineHydrochloride-0.01mg/kg group(n1), Nicardipine Hydrochloride-0.02 mg/kg group (n2), with each group 20 cases. BP, ECG, MAP and HR values, in the normal state, pre- anesthesia induction, post- Endotracheal Intubation (1, 3 and 5 min respectively), were supervised and recorded by the multifunctional noninvasive physiological monitor - DASH3000. Results Compared with the basal state parameters, significant decreases of MAP were seen in group n1 and group n2 after the application of Nicardipine Hydrochloride; the efficacy of group n2 was superior to that of group n1. HR increased obviously in group n1 and group n2 after the Endotracheal Intubation, but with no significant difference between group n1 and group n2.Conclusions The dosage of Nicardipine Hydrochloride, ranging from 0.01 mg/kg to 0.02 mg/kg, can be the effective dosage in the clinical prevention of Endotracheal Intubation induced BP increase. Key words: Nicardipine Hydrochloride; Endotracheal Intubation 盐酸尼卡地平是一种二氢吡啶类钙通道阻断剂，对血管平滑肌有较强的舒张作用，扩张小动脉，具有降压起效快、持续时间短等药理特点。该药用于缓解气管插管引起的心血管反应已有报道［1］，但给药时机和用药剂量各有不同，本文旨在观察盐酸尼卡地平用于防止气管插管反应的安全性和有效性。 1 资料方法 　　1.1 临床资料 　　选择择期非心脏手术，气管内插管全麻病人60例，男29例，女31例，年龄17～55岁，ASAⅠ～Ⅱ级，术前无明显高血压及冠心病史，未服用钙通道阴滞剂。 　　1.2 方法 　　1.2.1 实验分组 　　根据全麻诱导期静注盐酸尼卡地平剂量的不同，将60例患者随机将病人分成3组，即生理盐水对照组（n0）、盐酸尼卡地平0.01 mg/kg组（n1）、盐酸尼卡地平0.02 mg/kg组（n2），每组20例。盐酸尼卡地平