原创力文档accumulation of advanced glycation end (ages) products in intensive care patients an observational, prospective study积累先进的糖化结束(年龄)产品在重症监护病人的观察,前瞻性研究.pdfVIP
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accumulation of advanced glycation end (ages) products in intensive care patients an observational, prospective study积累先进的糖化结束(年龄)产品在重症监护病人的观察,前瞻性研究
Greven et al. BMC Clinical Pathology 2010, 10:4
/1472-6890/10/4
R E S E A R C H A R T I C L E Open Access
Research article
Accumulation of advanced glycation end (AGEs)
products in intensive care patients: an
observational, prospective study
1,2 2 1 1,3,4
Wendela L Greven* , Jitty M Smit , Johannes H Rommes and Peter E Spronk
Abstract
Background: Oxidative stress plays an important role in the course and eventual outcome in a majority of patients
admitted to the intensive care unit (ICU). Markers to estimate oxidative stress are not readily available in a clinical
setting. AGEs accumulation has been merely described in chronic conditions, but can also occur acutely due to
oxidative stress. Since AGEs have emerged to be stable end products, these can be a marker of oxidative stress. Skin
autofluorescence (AF) is a validated marker of tissue content of AGEs. We hypothesized that AGEs accumulate acutely
in ICU patients.
Methods: We performed an observational prospective study in a medical surgical ICU in a university affiliated teaching
hospital. All consecutively admitted ICU patients in a 2 month period were included. Skin AF was measured using an
AGE reader in 35 consecutive ICU patients 18 yrs. As a comparison, historical data of a control group (n = 231) were
used. These were also used to calculate age-adjusted AF-levels (AFadj). Values are expressed as median and interquartile
range [P25-P75]. Differences between groups were tested by non parametric tests. P 0.05 was considered statistically
significant.
Results: AFadj values were higher in ICU patients (0.33 [0.00 - 0.68]) than in controls (-0.07 [-0.29 - 0.24]; P 0.001). No
differences in skin AFadj were observed between acute or planned admissions, or presence o
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