an analysis of the positional distribution of dna motifs in promoter regions and its biological relevance分析的dna图案的位置分布及其启动子区域生物相关性.pdfVIP

BMC Bioinformatics BioMed Central Research article Open Access An analysis of the positional distribution of DNA motifs in promoter regions and its biological relevance 1 1,2 1 1 Ana C Casimiro , Susana Vinga , Ana T Freitas and Arlindo L Oliveira* Address: 1INESC-ID/IST, Rua Alves Redol, 9 1000-029 Lisboa, Portugal and 2FCM/UNL, Campo dos Mártires da Pátria 130, 1169-056 Lisboa, Portugal Email: Ana C Casimiro - ana.casimiro@; Susana Vinga - svinga@algos.inesc-id.pt; Ana T Freitas - atf@inesc-id.pt; Arlindo L Oliveira* - aml@inesc-id.pt * Corresponding author Published: 7 February 2008 Received: 17 August 2007 Accepted: 7 February 2008 BMC Bioinformatics 2008, 9:89 doi:10.1186/1471-2105-9-89 This article is available from: /1471-2105/9/89 © 2008 Casimiro et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Motif finding algorithms have developed in their ability to use computationally efficient methods to detect patterns in biological sequences. However the posterior classification of the output still suffers from some limitations, which makes it difficult to assess the biologica