antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from bryophyllum pinnatum抗菌和抗氧化活性的山柰酚rhamnoside衍生品从bryophyllum pinnatum.pdfVIP
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antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from bryophyllum pinnatum抗菌和抗氧化活性的山柰酚rhamnoside衍生品从bryophyllum pinnatum
Tatsimo et al. BMC Research Notes 2012, 5:158
/1756-0500/5/158
RESEARCH ARTICLE Open Access
Antimicrobial and antioxidant activity of
kaempferol rhamnoside derivatives from
Bryophyllum pinnatum
1* 2 3 4
Simplice Joel Ndendoung Tatsimo , Jean de Dieu Tamokou , Léopold Havyarimana , Dezső Csupor ,
4 4 2 5
Peter Forgo , Judit Hohmann , Jules-Roger Kuiate and Pierre Tane
Abstract
Background: Bryophyllum pinnatum (Lank.) Oken (Crassulaceae) is a perennial succulent herb widely used in
traditional medicine to treat many ailments. Its wide range of uses in folk medicine justifies its being called “life
plant“ or “resurrection plant“, prompting researchers’ interest. We describe here the isolation and structure
elucidation of antimicrobial and/or antioxidant components from the EtOAc extract of B. pinnatum.
Results: The methanol extract displayed both antimicrobial activities with minimum inhibitory concentration (MIC)
values ranging from 32 to 512 μg/ml and antioxidant property with an IC50 value of 52.48 μg/ml. Its partition
enhanced the antimicrobial activity in EtOAc extract (MIC = 16-128 μg/ml) and reduced it in hexane extract (MIC =
256-1024 μg/ml). In addition, this process reduced the antioxidant activity in EtOAc and hexane extracts with IC50
values of 78.11 and 90.04 μg/ml respectively. Fractionation of EtOAc extract gave seven kaempferol rhamnosides,
including; kaempferitrin (1), kaempferol 3-O-a-L-(2-acetyl)rhamnopyranoside-7-O-a-L-rhamnopyranoside (2),
kaempferol 3-O-a-L-(3-acetyl)rhamnopyranoside-7-O-a-L-rhamnopyranoside (3), kaempferol 3-O-a-L-(4-acetyl)
rhamnopyranoside-7-O-a-L-rhamnopyra
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