原创力文档association between different measurements of blood pressure variability by abp monitoring and ankle-brachial index联系不同测量血压变异性的abp监控和踝肱指数.pdfVIP
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association between different measurements of blood pressure variability by abp monitoring and ankle-brachial index联系不同测量血压变异性的abp监控和踝肱指数
Wittke et al. BMC Cardiovascular Disorders 2010, 10:55
/1471-2261/10/55
RESEARCH ARTICLE Open Access
Association between different measurements of
blood pressure variability by ABP monitoring and
ankle-brachial index
1,2 1,3 1,2* 1,2 1 1
Estefânia Wittke , Sandra C Fuchs , Flávio D Fuchs , Leila B Moreira , Elton Ferlin , Fábio T Cichelero ,
Carolina M Moreira1 1 1 1,2
, Jeruza Neyeloff , Marina B Moreira , Miguel Gus
Abstract
Background: Blood pressure (BP) variability has been associated with cardiovascular outcomes, but there is no
consensus about the more effective method to measure it by ambulatory blood pressure monitoring (ABPM). We
evaluated the association between three different methods to estimate BP variability by ABPM and the ankle
brachial index (ABI).
Methods and Results: In a cross-sectional study of patients with hypertension, BP variability was estimated by the
time rate index (the first derivative of SBP over time), standard deviation (SD) of 24-hour SBP; and coefficient of
variability of 24-hour SBP. ABI was measured with a doppler probe. The sample included 425 patients with a mean
age of 57 ± 12 years, being 69.2% women, 26.1% current smokers and 22.1% diabetics. Abnormal ABI (≤ 0.90 or
≥ 1.40) was present in 58 patients. The time rate index was 0.516 ± 0.146 mmHg/min in patients with abnormal
ABI versus 0.476 ± 0.124 mmHg/min in patients with normal ABI (P = 0.007). In a logistic regression model the
time rate index was associated with ABI, regardless of age (OR = 6.9, 95% CI = 1.1- 42.1; P = 0.04). In a multiple
linear regression model, adjusting for age, SBP and diabetes, th
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